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INCB-057643(Catalog#:A-6112)(Target:BET)(CAS#:1820889-23-3)INCB-057643isaninhibitoroftheBromodomain(BRD)andExtra-Terminal(BET)familyofBRD-containi...IDF-1174(Catalog#:A-1505)(Target:HIF-1α)(CAS#:1429054-28-3)IDF-1174inhibitsHSP70chaperoneactivityandsuppressesaccumulationofHIF-1α....LOXO-195(Catalog#:A-6100)(Target:TRK)(CAS#:2097002-61-2 )LOXO-195isasecondgeneration,selectiveTRKinhibitorcapableofaddressingpotentialmechanisms...MIK-665(S-64315)(Catalog#:A-1457)(Target:MCL-1)(CAS#:1799631-75-6)MIK-665(S-64315)isaninhibitorofinducedmyeloidleukemiacelldifferentiationprotein(Mcl-1;B...AZD-5991(Catalog#:A-6097)(Target:MCL-1)(CAS#:2143061-81-6)AZD-5991isapotentandselectiveMCL-1inhibitor,withpotentialpro-apoptoticandantineoplastic...E-7386(Catalog#:A-1341)(Target:CBP/ß-catenin)(CAS#:1799824-08-0)E-7386isaselectiveinhibitorforCBP/ß-catenincomplexformation,thatmodulatestheß-cateninde...Rocaglamide(Catalog#:A-1624)(Target:NF-κB)(CAS#:84573-16-0)Rocaglamideisanimmunosuppressant,andapotentinhibitorofNF-κBactivationinTcells,withan...E-7090(Catalog#:A-6063)(Target:FGFR)(CAS#:1622204-21-0)E-7090isaselectiveinhibitorofthetyrosinekinaseactivitiesofFGFR1,-2,and-3....CB-1158(Catalog#:A-6098)(Target:Arginase)(CAS#:2095732-06-0)CB-1158isapotentinhibitorofhumanarginase(IC50=98nM).Inculture,humangranulocytesrelea...BAY-1816032(Catalog#:A-1166)(Target:BUB1)(CAS#:1891087-61-8)BAY-1816032isapotentandselectiveBUB1(Mitoticcheckpointserine/threonine-proteinkinase)inhi...IPI-926(Saridegib)(Catalog#:A-1062)(Target:Hedgehog)(CAS#:1037210-93-7)IPI-926(Saridegib)isanorallybioavailableinhibitoroftheHedgehog(Hh)pathwaywithpotential...BLU-285(Catalog#:A-1222)(Target:KIT;PDGFRα)(CAS#:1703793-34-3)BLU-285isapotentandselectiveinhibitorofPDGFRα(D842V)andKITExon17mutants....PD-1/PDL-1Inhibitor1(Catalog#:A-9111)(Target:PD-1/PDL-1Interaction)(CAS#:1675201-83-8 )PD-1/PD-L1inhibitor1isasmall-moleculeinhibitorofPD-1/PD-L1interactionatIC50of6nM....S-63845(Catalog#:A-6044)(Target:MCL-1)(CAS#:1799633-27-4 )S-63845isapotentandselectiveMCL1inhibitor(Ki(MCL1,FP)<1.2nM;Kd(MCL1,SPR)=0.19nM;...FF-10101(Catalog#:A-9114)(Target:FLT3)(CAS#:1472797-69-5(freebase))FF-10101isanovelirreversIBLeFLT3inhibitor,andshowsexcellentefficacyagainstAMLcellswith...(+)-EtomoxirSodiumSaltHydrate(Catalog#:A-1672)(Target:CPT1)(CAS#:828934-41-4)...ARS-1620(Catalog#:A-1671)(Target:K-RAS(G12C))(CAS#:1698055-85-4)ARS-1620isapotentandirreversibleinhibitorofmutantK-RAS(G12C)throughacovalentbondwitht...THZ-531(Catalog#:A-1670)(Target:CDK12;CDK13)(CAS#:1702809-17-3)...EPZ-031686(Catalog#:A-1669)(Target:SMYD3;MEKK2)(CAS#:1808011-22-4)EPZ-031686isanoncompetitiveinhibitorforSMYD3andMEKK2withaKi=1.2and1.1nMrespectively....eFT-226(Catalog#:A-1668)(Target:eIF4A)(CAS#:)eFT-226isaselectiveandhighlypotentinhibitorofeukaryoticinitiationfactor4A(eIF4A),anov...